Tramadol’s duration of efficacy varies between dosage forms, with Tramadol tablets lasting about 4 to 6 hours and Tramadol extended-release tablets lasting about 12 hours. Tramadol is a centralized opioid analgesic used primarily for the short-term (5 days or less) treatment of moderate to severe acute pain. The duration of the drug’s effect is affected by the dosage form, e.g., the duration of the drug’s effect is about 4 to 6 hours for Tramadol tablets and about 12 hours for Tramadol extended-release tablets. Adverse reactions to this product include nausea, vomiting, abdominal pain, headache, malaise, and fever. Note that it is contraindicated in people who are allergic to the product, children under 12 years of age, people with gastrointestinal obstruction, severe respiratory depression, and severe brain damage. Tramadol belongs to the psychotropic controlled drugs, it is recommended to use the drug under the guidance of a physician, and not to take the drug blindly on your own.