Morpholine generic name is domperidone, domperidone and mosapride are both gastrointestinal power promoting drugs, which drug is good, need to be based on the individual patient’s specific situation. Domperidone is the first generation of drugs to promote gastric power, mainly in the periphery of the dopamine receptor antagonist, direct action on the stomach wall, mainly in the stomach, with the promotion of gastric emptying, enhance gastric dynamics and sphincter tone, and then to prevent food reflux, mostly used for dyspepsia, gastrointestinal motility caused by the symptoms of slow. Domperidone adverse reactions: hypersensitivity to the product, pregnant women, mechanical gastrointestinal obstruction, gastrointestinal bleeding, perforation, pheochromocytoma, as well as moderate or severe hepatic insufficiency is prohibited. Adverse reactions include headache, fatigue, dizziness, malaise, and diarrhea. It is recommended to take it within 15 to 30 minutes before meals. Mosapride is a third-generation drug that promotes gastric motility, acting on the entire gastrointestinal tract is a selective 5-HT4 receptor agonist, so the scope of Mosapride’s action is wider than that of morpholine, in addition to being used for dyspepsia, epigastric distension, heartburn, early satiety, hiccups, vomiting, and other symptoms, it can also be used for constipation of the intestinal tract. Mosapride adverse reactions: it is contraindicated in patients who are allergic to this drug, gastrointestinal bleeding, gastrointestinal perforation and intestinal obstruction. Adverse reactions include diarrhea, abdominal pain, and dizziness. This medication should be discontinued immediately if there is no change in gastrointestinal symptoms after two weeks of administration. Which of the two drugs is better should be based on factors such as specific symptoms, etiology and one’s own condition, and should be taken in accordance with the doctor’s instructions to avoid adverse reactions and delays.