Taking antiviral drugs for hepatitis B carriers for a long time has some side effects. Side effects vary depending on the drug, such as adefovir, lamivudine, entecavir and so on. 1. adefovir: adefovir’s main adverse reactions in the clinic are headache, gastrointestinal adverse reactions, fatigue, etc. It can be manifested as a decrease in the number of white blood cells in the blood, an increase in creatine phosphokinase and so on. 2. Lamivudine: the main clinical side effects of lamivudine are headache, insomnia, anemia, thrombocytopenia, cough, increased aminotransferase levels, skin rash, hair loss, etc. 3. entecavir: entecavir’s adverse reactions are mainly manifested as osteoporosis, hypophosphatemia and renal function damage, but relatively speaking, the side effects are relatively small, and it is not easy to produce drug resistance, it is the first line of antiviral drugs recommended by the current guidelines. Taking antiviral drugs for hepatitis B carriers, discomfort, it is recommended to consult the Department of Infectious Diseases of the regular hospital in a timely manner.