Generally speaking, a temperature of 37.5°C after taking the 13-valent pneumonia vaccine is a normal post-vaccination adverse reaction, but it varies from person to person. Pneumonia 13-valent vaccine actually contains heterogeneous proteins, still has a certain antigenicity, after injection into the human body will cause a certain degree of immune response, resulting in a mild fever, which is a relatively normal phenomenon. And fever or not and the degree of fever is related to personal constitution, some people may have fever, usually lasts for 1-3 days will be automatically relieved, but some people will not. It is worth noting that if the body temperature is too high or the fever persists, it is recommended to go to the hospital in time and take fever-reducing medication or relevant treatment measures under the guidance of the doctor.