Patients with itchy blisters on the palms of the hands may be caused by herpes sweat, eczema, fungal infections of the hands, palmoplantar pustulosis and so on. 1. Herpes sweat: herpes sweat is a blistering skin disease that occurs symmetrically on the palms of the hands, soles of the feet and lateral edges of the fingers and toes, and itchy blisters on the palms of the patients may be caused by herpes sweat. 2. Eczema: eczema is caused by a variety of internal and external factors of the superficial dermis and epidermal inflammation, patients with eczema on the hands, may lead to blisters on the palms of the hands, itchy situation. 3. Fungal infection of the hands: Fungal infection of the hands may also cause localized itching, erythema, papules, blisters and so on. 4. Palmoplantar pustulosis: it may be related to immune system disorders, heredity, infection, allergy, smoking, etc., which can also lead to itchy blisters on the palms of the hands. It is recommended that patients seek timely medical examination to clarify the cause of the targeted treatment, pay attention to personal hygiene in life, avoid excessive friction, scratching the affected area, and at the same time do a good job of monitoring the condition of the patient, if there is any abnormality, timely follow-up.