Blue sclera refers to the light blue color of the sclera of the eye under normal natural light, and it is an external manifestation of Rubinstein-Taybi syndrome. Patients with blue sclera need to go to the hospital for examination in time to avoid Rubinstein-Taybi’s syndrome disease getting more and more serious. The methods to check blue sclera are: 1. Physical examination Focus on the changes of sclera, as well as the changes of conjunctiva, cornea, uvea, retina and optic disc. 2.Auxiliary examination Full blood count, blood sedimentation, rheumatoid factor, anti-nuclear antibody, anti-neutrophil cytoplasmic antibody, blood uric acid test, routine blood test, etc. can be chosen. It can effectively check whether there is anemia and the severity of anemia, and whether it is accompanied by changes in the number of white blood cells or platelets. Peripheral blood smear can observe changes in the number or morphology of red blood cells, white blood cells and platelets, and whether there are malaria parasites and abnormal cells. For patients with blue sclera, ultrasound examination, CT scan or MRI examination can also be performed to further confirm the diagnosis. Warm tip: If the blue sclera is congenitally inherited in combination with other eye diseases, symptomatic treatment is available.