Surgery is the mainstay for early-stage patients, and adjuvant therapy is chosen after surgery according to the presence of high-risk factors. The high-risk factors affecting the prognosis of endometrial cancer include: non-endometrioid adenocarcinoma, high-grade adenocarcinoma, myometrial infiltration more than 1/2, choroidal interstitial invasion, tumor diameter greater than 2 cm, cervical interstitial invasion, lymph node metastasis and extra-uterine metastasis. Advanced stage patients are treated with a combination of surgery, radiation and drugs. For young patients with highly differentiated endometrioid carcinoma whose lesions are confined to the endometrium as assessed by imaging, progesterone therapy-based treatment for preservation of fertility can be considered. 1.Surgical treatment: It is the preferred treatment method. The purpose of surgery: first, to perform surgical pathological staging to determine the extent of lesions and prognostic factors, and second, to remove the diseased uterus and other possible metastatic lesions. The basic procedure for lesions confined to the body of the uterus is extrafascial total hysterectomy and bilateral adnexal resection, but in young patients without high-risk factors, preservation of the ovaries can be considered; for those with high-risk factors, pelvic and para-aortic lymph node dissection should be performed simultaneously, and mapping biopsy of the anterior lymph nodes can also be considered to avoid complications caused by systemic lymph node dissection. Modified extensive hysterectomy, bilateral adnexal resection, and pelvic and para-aortic lymph node dissection are performed for lesions invading the interstitial cervical space. For lesions beyond the uterus, tumor cytoreductive surgery is performed to remove all visible lesions as much as possible. 2.Radiotherapy: It is one of the effective methods to treat endometrial cancer. Radiotherapy alone is only used for advanced patients who have contraindications to surgery or cannot be removed surgically; postoperative radiotherapy can reduce local recurrence and improve tumor-free survival; for advanced patients, the combined application of radiotherapy, surgery and chemotherapy can improve the efficacy. 3.Chemotherapy as systemic treatment: it is applicable to patients with advanced or recurrent endometrial cancer, and can also be used for the treatment of patients with high risk factors of recurrence after surgery, in order to reduce distant metastasis outside the pelvis. 4.Progestin therapy: It is mainly used for early stage endometrial cancer patients with preserved reproductive function, and can also be used as one of the comprehensive treatments for patients with advanced or recurrent endometrial cancer. Surgery is preferred in early stage of endometrial cancer patients, and corresponding adjuvant treatment is selected according to the presence or absence of high-risk factors affecting prognosis; advanced patients are treated with a combination of surgery, radiation and drugs.