Pantoprazole is used in the treatment of active peptic ulcers and reflux esophagitis, and should not be used in combination with antiretroviral drugs, anticoagulants, antibacterials, and certain other drugs. 1. Antiretroviral drugs: such as lamivudine, nelfinavir, and atazanavir, which can cause the efficacy of pantoprazole to be compromised. 2. Anticoagulant drugs: such as warfarin and pantoprazole sodium, once taken with pantoprazole, tend to increase the prothrombin time, which may lead to an increased risk of bleeding. 3. Antifungal drugs, such as itraconazole and calcium carbonate, combined with pantoprazole will lead to a decrease in the pH value of the stomach, affecting the absorption and utilization of drugs. 4. Certain other drugs: such as calcium carbonate, pantoprazole will inhibit the free calcium ion in calcium carbonate, can not be combined with phosphate, affecting the therapeutic effect. Pantoprazole more common adverse reactions include occasional dizziness, insomnia, nausea, constipation, and skin rashes, etc., lactation and pregnancy women are prohibited. In addition, the above medications carry certain risks and should be used under the supervision of a medical specialist.