The need for treatment for HFMD is not based on fever; some patients can recover spontaneously without treatment; if there is no fever but there are other symptoms, treatment is needed. HFMD is caused by enterovirus infections and is mainly spread through close contact and respiratory droplet transmission. The prognosis of HFMD is usually good. Mild cases do not require special treatment and can be cured within 7 to 10 days without sequelae. Therefore, those with mild disease and no fever do not need treatment and can be followed up for observation. If HFMD patients do not have fever symptoms, but accompanied by other uncomfortable symptoms, usually can be prescribed with mannitol, furosemide and other drugs to reduce intracranial pressure, but also with methylprednisolone, hydrocortisone and other glucocorticosteroids, if appropriate, treatment. Since the disease is contagious, it is important to isolate the patient during the illness and avoid close contact with other healthy people. It is recommended that those who are diagnosed with HFMD should cooperate with their doctors and take appropriate measures according to their actual conditions.