The main mechanism of opioids is to inhibit the central nervous system, and after poisoning, it is necessary to be admitted to the hospital in time to quickly detoxify and save the patient’s life. Specific treatment measures are as follows: 1, clear poisoning pathway, in order to quickly detoxification: such as oral poisoning, need to carry out gastric lavage, diarrhea, rehydration and other treatments; 2, pay attention to the patient to keep warm; 3, to maintain a smooth respiratory tract, active and effective oxygen inhalation; 4, severe poisoning of the patient, can be given to hemodialysis and blood perfusion, and early application of opioid antidote naloxone.