Early stage of uremia is also known as the failure stage of chronic renal insufficiency, which mainly refers to the creatinine between 221-442umol/L and glomerular filtration rate between 10%-25%, and the patients in this stage have already had the symptoms of edema, elevated blood pressure, nausea, vomiting, anemia, metabolic acidosis and so on; while late stage of uremia refers to the end stage of renal insufficiency. The progression from early uremia to advanced uremia usually takes no more than 3 years. If there are infection, nausea, vomiting, diarrhea, poor blood pressure control and other factors involved, this time may be shorter, some even a few months. Therefore, if the patient is in the early stages of UTI, it is recommended that the above aggravating factors must be avoided. It is also recommended to perform endovascular fistuloplasty to prepare for long-term hemodialysis.