Methotrexate belongs to a kind of chemotherapeutic drug, and its side effects include effects on the blood system, there may be a drop in white blood cells and platelets, and the patient may suffer from anemia, as well as hemorrhage and sepsis. There are also gastrointestinal adverse reactions, after the use of nausea, vomiting, loss of appetite, and some patients may even develop peptic ulcers. There is also damage to liver and kidney function, after use, liver function may be impaired, manifested as elevated aminotransferases, but also may be manifested as impaired renal function, oliguria, or even electrolyte disorders, cystitis and so on. Some female patients may experience other adverse reactions such as menstrual disorders, skin rashes, etc. The specific adverse reactions and side effects may vary according to the patient’s physical condition.