Patients with early periampullary cancer often have no symptoms, and the earliest painless jaundice, i.e. yellow urine, yellow eyes or generalized yellowing, appears after causing bile duct obstruction. Patients with jaundice are usually painless and have no uncomfortable manifestations. If the staging is early, patients do not always have significant symptoms. Patients with advanced stages have more symptoms and may have symptoms of infection, abdominal pain and fever. Patients with advanced stage can cause wasting and may also cause vomiting and other manifestations when the tumor compresses the intestine. If painless jaundice of unknown origin occurs, patients should pay attention to the pot-belly aspect of examination, and some patients need to do further examination, most commonly ultrasound examination, and further confirmation needs to perform CT, MRI, ERCP and other examinations.