What is peri-pot belly cancer? Peri-pot belly cancer refers to cancer in the pot belly, the lower end of the common bile duct, the opening of the pancreatic duct, the duodenal papilla and the nearby duodenal mucosa. These tumors of different origins have the same clinical manifestations due to their special anatomical locations, and it is difficult to separate them during surgery, so they are often referred to as one type of periampullary carcinoma. What causes peri-pot belly cancer The cause of this disease is still unknown and may be related to several factors.