Peri-potbelly cancer and pancreatic head cancer are also relatively common as well as serious diseases in hepatobiliary surgery. The difference between periampullary cancer and pancreatic head cancer is firstly different in terms of location, that is, the source. Pancreatic head cancer originates from the pancreas, and the malignancy of pancreatic head cancer is very high. Peripancreatic cancer originates from the lower part of the common bile duct, as well as the jugular abdomen, the duodenal papilla or the descending part of the duodenum, and tumors in this area are collectively called peripancreatic cancer. Some patients have undergone radical pancreaticoduodenectomy, but the five-year survival rate is very low, which varies from one literature to another. In general, the five-year survival rate may be 10% or even less than 10%. For periampullary cancer, if radical surgical resection is performed, the five-year survival rate is about 40% with better results.