Treatment of migraine includes attack mitigation or termination, as well as prevention of migraine recurrence and relief of accompanying symptoms. Treatment during attacks: General analgesics such as NSAIDs and opioids can stop attacks. In case of ineffectiveness, treprostans and ergot alkaloids may be effective, but they are powerful vasoconstrictors that constrict dilated intracranial arteries and are contraindicated in patients with hypertension and cardiovascular disease. In addition, some new anti-migraine drugs such as ticagrepam and osegepam are also effective. Preventive treatment: It is suitable for patients with frequent attacks that seriously affect their normal life and work. Mainly include: ① Eliminate triggering factors such as light: tension, lack of sleep, fasting, noise, strong odor stimulation, oral contraceptives and vasodilators, avoiding cheese containing tyramine, meat and pickled food containing nitrite, chocolate containing phenylethylamine, food additives containing monosodium glutamate and wine, keeping an open mood, quitting smoking and alcohol, etc. ②Medications: antidepressants such as amitriptyline, promethazine and sertraline are suitable for patients with frequent migraine attacks combined with tension headache. Β-blockers such as propranolol, antiepileptic drugs such as valproic acid and topiramate, and calcium antagonists such as nimodipine. Treatment of concomitant symptoms: Nausea is the most common concomitant symptom of migraine, which can be treated by intramuscular injection of antiemetic Gastrodia, and in severe cases, small doses of Endrin and Chlorpromazine. In conclusion, in order to achieve better treatment effect, migraine patients should seek timely medical consultation, receive standardized and systematic treatment, and avoid various triggering factors.