The cause of high thyroglobulin antibodies may be an autoimmune thyroid disease caused by the immune system attacking the thyroid tissue, such as Hashimoto’s thyroiditis, hyperthyroidism, etc. Symptoms vary from cause to cause. Patients with high thyroglobulin antibodies may have symptoms such as fatigue, drowsiness, insomnia and palpitations. 1. Hashimoto’s thyroiditis: the thyroid gland is enlarged, which may lead to respiratory difficulties if it presses on the trachea. Hashimoto’s thyroiditis with hypothyroidism may also present with drowsiness, fatigue, weight gain, bradycardia, and constipation. Most people with hypothyroidism are followed up regularly, and those with hypothyroidism may be treated with thyroid hormone replacement therapy. 2. Hyperthyroidism: symptoms such as insomnia, palpitations, hyperphagia, increased frequency of bowel movements, fear of heat, and weight loss may occur. It can be treated with antithyroid drugs, iodine 131 and surgery. 3. There are simple high thyroglobulin antibodies, but thyroid function and thyroid ultrasound are normal without any clinical symptoms. Patients with high thyroglobulin antibodies are recommended to go to regular hospitals in time to improve the thyroid function, thyroid ultrasound and other examinations, and then carry out standardized treatment after clarifying the cause of the disease under the guidance of doctors.