Chromosomal abnormalities may occur in a child born after becoming pregnant while taking TB drugs, and it may be a Down’s baby, a fetus with trisomy 21. Anti-tuberculosis drugs may cause chromosomal abnormalities, and the drugs can cross the placental barrier, which can lead to the occurrence of fetal malformations, stillbirths, and miscarriages, so it is generally recommended that pregnancy occur after six months of stopping anti-tuberculosis drug therapy. Down syndrome is a type of chromosomal abnormality that occurs when chromosome 21 does not segregate during meiosis in the germ cells of either the father or the mother or during mitosis in a fertilized egg, resulting in trisomy 21, also known as Down’s syndrome, a type of chromosomal abnormality. Pregnancy is usually not recommended during anti-tuberculosis treatment, and if you are pregnant and want to have a baby, it is important to pay attention to prenatal diagnosis as well as regular labor and delivery tests.