Weak pulse is due to the deficiency of Yang Qi and Yin Blood, the Qi and Blood are unable to spread outside and the pulse is sunken; the pulse is thin and weak due to the weakness of the filling and bulging. The pulse comes to be thin, soft and sunken, soft and slippery. Those who have weak pulse may be deficient in both qi and blood, should benefit the qi and blood, blood circulation, nourish the liver and kidneys, promote metabolism, improve blood microcirculation, and timely discharge the pigment and human waste deposited in the skin out of the body. Prevention: 1. First of all, education on nutrition should be strengthened to correct partial eating habits and incorrect cooking habits. Infants should promote breastfeeding, reasonable feeding, timely addition of complementary foods. 2. Pregnant women should eat more fresh vegetables and animal protein, and supplement folic acid in late pregnancy. 3.Improvement of recipes should be actively promoted in areas with high prevalence of nutritional megaloblastic anemia. 4.People with chronic hemolytic anemia or long-term anti-epileptic drugs should be given folic acid prophylaxis, and those with total gastrectomy should be given prophylactic intramuscular injection of vitamin B12 once a month. 5.To carry out population screening, genetic counseling and pre-marital guidance to avoid marriage between the carriers of the gene of the earth poverty is important for the prevention of this disease. 6.Prenatal diagnosis by genetic analysis can diagnose heavy β and α fetuses in early pregnancy and interrupt the pregnancy in time to avoid the occurrence of fetal edema syndrome and the birth of heavy β fetuses, which is an effective method to prevent weak pulse at present.