The main contents of “Tumor Channel” include academic lectures, case discussions, medical conferences, surgical operations, and health education lectures for patients and their families. At the same time, “Tumor Channel” invites famous experts in the field of tumor and pharmaceutical enterprises to work together to build “Tumor Channel” into an academic exchange platform in the field of tumor! Pancreatic tumors, due to their high insidiousness, often enter the local progressive or metastatic stage when they are detected, which is difficult to be effectively treated by existing means and has a very poor prognosis. Recently, a new technology called “irreversible electroporation technology” (also known as nano-knife) has been registered by China Food and Drug Administration and officially landed in China. On August 17, the Cancer Center of the First People’s Hospital of Shanghai Jiaotong University successfully performed the “Nano-knife” treatment surgery for a 67-year-old patient with progressive pancreatic ductal cancer. It is reported that this surgery is the first of its kind in Shanghai and has the advantages of not damaging the surrounding blood vessels and normal cells of nerves, less complications and more thorough treatment, which is expected to bring hope to more than 80,000 pancreatic cancer patients in China. On the afternoon of the 17th, a 67-year-old male patient was lying on the CT examination bed, and experts such as Professor Kevin Huang from National Taiwan University Hospital, affiliated with National Taiwan University College of Medicine, and Professor Wang Liwei, the discipline leader of the Oncology Center of the First People’s Hospital of Shanghai Jiaotong University, were having the final discussion. It is understood that the patient was found to have a pancreatic tumor one month ago, located in the head and neck of the pancreas, which invaded the adjacent blood vessels and could not be removed surgically, and was referred to the Pancreatic Cancer Diagnostic and Treatment Center of the First People’s Hospital of Shanghai Jiao Tong University from an outside hospital. He was referred to the Pancreatic Cancer Center of the First People’s Hospital of Shanghai Jiao Tong University from a foreign hospital. In order to ensure the smooth operation, Prof. Wang Liwei organized a consultation and discussion with Prof. Chen Lianhua from the Department of Anesthesiology, Prof. Sun Xing from the Department of Hepatobiliary and Pancreatic Surgery, Prof. Shi Qiusheng from the Department of Ultrasound, Prof. Wang Hum from the Department of Radiology, Prof. Wan Zhiyong and Prof. Wang Hongxia from the Cancer Center, and formulated a perfect treatment plan and determined the operation plan and post-operative care and other related plans. The principle of “NanoKnife” is to generate pulsed high-voltage current through 5 puncture needles evenly distributed in and around the lesion to break the tumor cell membrane, forming nano-scale irreversible electroporation, and finally causing the tumor to apoptosis and replaced by new healthy cells. Therefore, the precise insertion of the probe is the key to the success or failure of the operation, which is to completely include the lesion in the scope of the current network while avoiding zapping the surrounding blood vessels and nerves. 13:00, the operation officially started, and Deputy Chief Physician Wang Hong of the Department of Anesthesiology presided over the anesthesia. Professor Shi Qiusheng, Executive Director of Southern Ultrasound Department of the First People’s Hospital of Shanghai Jiaotong University, determined the lesion and the proposed needle location with bedside ultrasound. Under the guidance of ultrasound combined with CT, Dr. Zhiyong Wan, chief physician of the Department of Interventional Oncology, precisely inserted five 19-gram puncture needles with a diameter of only 1.2 mm into the lesion and its surroundings one after another, avoiding the surrounding blood vessels. Afterwards, Prof. Wang Liwei activated the switch and several microsecond high-voltage pulses instantly penetrated the lesion, “punching” numerous nano-scale electroporation holes in the tumor cell membrane. Over the next 14 days, these tumor cells will gradually die and be replaced by new healthy cells. The whole treatment process lasted for more than 2 hours, and the patient returned to the ward safely. The oncology center will further combine with other treatments to strengthen local control and prevent distant metastasis, and finally prolong the patient’s survival and improve the patient’s quality of life. It is understood that the biggest advantage of “Nano Knife” technology is its specificity, the pulsed high voltage current generated by it only acts on tumor cells specifically expressed by the tumor and will not injure the surrounding normal organs. This is because normal cells contain more collagen in connective tissue and elastic fibers, and their cell membranes lack lipid bilayers that produce irreversible electroporation, therefore, no “accidental injury” will occur during nanoknife treatment, which is very suitable for tumors in the hilar region, adjacent to the gallbladder and bile duct, pancreatic duct and ureter that cannot be operated. In addition, since there is no thermal effect, it also protects the blood vessels around the tumor and even inside the tumor, bile duct and pancreatic duct, and the complications are significantly reduced. As a completely new treatment combining minimally invasive and biological characteristics of tumor, NanoKnife can greatly prolong the survival time of patients and improve the survival quality of patients with locally progressive pancreatic cancer, bringing a new light to patients with inoperable locally progressive pancreatic cancer.