As the saying goes, “ten women have nine spots”, and spots are a serious problem for women who love beauty. Many customers hope that their skin can be instantly whitened and spotless when they use whitening and spot removal products and go to beauty salons for care, which seems to be the effect only when this degree is achieved. 1, tyrosinase inhibitors such as: hydroquinone (hydroquinone), azelaic acid, 4-isopropyl catechol, etc. through the inhibition of tyrosinase to achieve the purpose of inhibiting melanin, skin whitening. Most of the topical blemish removal creams sold in the market contain the above-mentioned ingredients plus some plant extracts such as arbutin; 2, oxidizing agents: such as 1-3% hydrogen peroxide solution, 30-50% sodium nitrite solution, through the formation of strong oxidizing ability of free hydroxyl groups to destroy the basic molecular structure of proteins to achieve the role of decolorization; 3, mercury preparations: 1-2% mercury dichloride through mercury ions and microbial protein hydrogen group Combined with microbial protein hydrogen group, it interferes with cellular protein to play the role of decolorization, and is used to treat freckles and chloasma. 4. Non-tyrosinase inhibitors: Vitamin A acid, vitamin C and plant extracts such as ginkgo biloba extract are used to remove spots. At present, there are many instant whitening and spot removal products on the market, but some of the untested whitening and spot removal products contain hydroquinone, mercury and other decolorizing ingredients, which often exceed the standard, bleaching the skin in the short term, making the skin color look much whiter, but in fact, the outer layer of the epidermis is stripped of the protective layer of sebaceous membrane, that is, the natural protective coat of the skin is stripped, and the red blood cells of the skin cells are also damaged by the bleaching ingredients, resulting in the epidermal metabolism, the decline in function, melanin deposition, keratosis, and the loss of skin cells. The skin condition becomes worse as the function of the epidermis declines, melanin is deposited, and the stratum corneum becomes thinner. Moreover, mercury, a toxic heavy metal, can be absorbed through the skin and deposited in the body with cosmetics, causing chronic mercury poisoning, which can have harmful effects on the nervous, digestive and endocrine systems and kidneys. The long-term use of cosmetics with excessive mercury content by pregnant and lactating women can be extremely harmful to the health of fetus and baby. Besides, chloasma (stretch marks) caused by endocrine changes cannot be removed by spot removal cream alone, but also through internal and external treatment to slowly achieve the purpose of removing spots and whitening. Therefore, do not easily believe in the lie of “removing spots in a few days and whitening quickly”. Experts suggest that the removal of spots is appropriate for each person and treated according to the spots: 1, endocrine changes caused by chloasma (commonly known as butterfly spots), the selection of beauty products to remove spots at the same time need to be under the guidance of a specialist in the internal regulation of drug treatment; 2, freckles: in addition to the use of tyrosinase inhibitors of skin whitening products, professional medical version of photon therapy instrument, the application of selective photothermal principle, non-destructive and painless selective removal of freckles; sun spots, chloasma, etc. Sun spots, chloasma, etc. can be treated with pulsed laser with fruit acid skin cycle, using the selective destruction of pigment tissue by laser at different depths of pigment tissue without hurting the surrounding normal tissue to achieve the purpose of pigment fading. 3.Secondary pigmentation: such as post-inflammatory hyperpigmentation, sun spots, etc., non-tyrosinase inhibitor skin whitening products can be used: such as vitamin A acid, spot removal products containing vitamin C, plant extracts containing mulberry extract, ginkgo biloba extract, etc.