Taking statin direct bilirubin high in all three items is considered to be possibly related to its side effects, or pathological factors such as liver disease, biliary tract disease, hemolytic jaundice. The main drug treatment and surgical treatment. 1. Statin side effects: some patients will have abnormal liver function after oral intake, resulting in high bilirubin in all three items, generally stop applying statin drugs, liver function will return to normal. 2. Pathologic factors: (1) Liver diseases: such as viral, alcoholic hepatitis, cirrhosis, hepatocellular carcinoma, etc., will lead to different degrees of damage to liver cells, so that the bilirubin in the blood is high in all three items, and generally need antiviral and hepatoprotective enzyme-lowering drug therapy, such as entecavir, glycyrrhizin, etc., and oral intake of nausea, dry vomiting, headache, skin rash and other adverse reactions may occur. (2) Biliary tract diseases: such as cholecystitis, gallstones, bile duct tumors, etc., can cause direct, indirect, total bilirubin together with the phenomenon of elevation, generally cholecystitis need anti-infection treatment, such as levofloxacin, after the application of nausea, skin rash, headache and other adverse reactions may occur. Gallstones and bile duct tumors are usually treated with surgery. (3) Hemolytic jaundice: when red blood cells are destroyed, hemoglobin will be converted into indirect bilirubin, thus causing high bilirubin, usually applying glucocorticoid treatment, such as prednisone, etc., which may cause obesity, nausea, vomiting and other adverse reactions after oral intake. All of the above drugs should be applied under the guidance of a doctor, if the phenomenon of elevated bilirubin, it is recommended to go to the hospital as soon as possible.