Herpes simplex does not work with erythromycin ointment because herpes simplex is a disease caused by herpes simplex virus infection, and antiviral medications need to be chosen to relieve the symptoms. Herpes simplex is usually characterized by clustered blisters that heal on their own, but it is prone to recurrence, especially when the patient is immunocompromised, traumatized and overworked. For patients with herpes simplex disease, they may recover untreated, but some patients with more severe conditions need to cooperate with their doctors in choosing antiviral medications, such as acyclovir, vasiclovir, and famciclovir, to shorten the course of the disease. Erythromycin ointment is not as herpes simplex medication choice, it is recommended that after the discovery of herpes simplex, the patient should cooperate with the doctor to standardize the treatment, not blindly use the drug, in order to avoid adverse effects.