Many people have experienced anal itching, an unspeakable painful and embarrassing experience. Especially at night, the itching increases and it is difficult to sleep. The itch is actually more unpleasant and troublesome than the pain. Pain has a cause to find, there are drugs to cure, but the itch can not, the cause is complex, itch drugs are difficult to find, especially the persistent anal itch. There are many causes of anal itching, both primary and secondary. The primary ones are mostly seen in local allergies, perianal or intestinal secretions and chronic inflammatory evidence stimulation, perianal diseases and stimulation by iodine, alcohol, strong alkali and other substances. Secondary ones are mostly seen in allergic reactions caused by food, drugs or certain allergenic substances, endocrine disorders, malnutrition, digestive disorders, intestinal parasites, neurological dysfunction, overwork, mental tension, depression, insomnia, etc. Persistent anal itching is mostly primary. Many of the disease is considered trivial, either ignore it and let it develop, or go to the pharmacy or hospital to prescribe some anti-itch creams. Some patients like to scald with hot water, feeling very relieved itch. In fact, all of them are wrong. Mild or early itching is relatively easy to treat, once the prolonged days into a stubborn itch, treatment is very difficult. The topical ointment can not be used casually, many are hormone-containing, can not be used for a long time, long-term use will aggravate the condition, so that the itch to expand the range. Hot water will damage the local skin and make the itching worse. Mild anal itching can be applied with pepper brine and anti-allergy creams, most of which quickly stop itching. But some prolonged days, accompanied by skin thickening, leather-like changes in the stubborn anal itch, it is very difficult to do, although there are some Chinese and Western drugs, but the effect is not good, easy to repeat. In our clinical practice, we adopt the unique compound drug local subcutaneous injection, which has achieved very satisfactory results, with 100% efficiency for persistent itch that has been ineffective for a long time, and a cure rate of up to 90% with one injection, and the cumulative treatment cases have reached more than 500, with a recurrence rate of less than 5% in the one-year follow-up after the operation. At present, we are carrying out treatment by ion drug introduction method, which can deliver special drugs to the itchy skin subcutaneously without any sensation and play a therapeutic role, without the need for hospitalization, and can really realize the treatment as you go.