There is no therapeutic effect of taking Prevacid for leg numbness caused by lumbar disc herniation. The numbness of the lower limbs caused by lumbar disc herniation is mainly due to the nucleus pulposus, annulus fibrosus and cartilage plate in the lumbar intervertebral disc, especially the nucleus pulposus. There are different degrees of degenerative changes, under the action of external forces, the intervertebral disc fibrous ring rupture, the nucleus pulposus tissue from the rupture place protrudes (or out) in the posterior or the spinal canal, leading to the adjacent spinal nerve root suffers from irritation or compression, resulting in a side of the lower limbs or both lower limbs numbness. Pregabalin, on the other hand, is an analgesic medication that is used clinically to treat postherpetic neuralgia, peripheral neuralgia or adjunctively to treat limited partial seizures. Therefore, Pregabalin has no therapeutic effect on leg numbness caused by lumbar disc herniation, for such symptoms, it is recommended to seek regular treatment in the hospital as soon as possible.