It is not recommended to take ibuprofen after drinking alcohol. Alcohol begins to be metabolized after four hours, but people who drink excessively cannot tell when the alcohol is metabolized. For safety reasons, if you must take ibuprofen, take the medication the day after you have consumed alcohol. Since it takes a day for the body to metabolize, it is safer to take ibuprofen at least 24 hours after drinking. Alcohol and drugs can produce chemical reactions that have a very strong impact on the internal organs of the body, the most harmful of which is the spleen and stomach, and serious alcohol reactions can even lead to symptoms of shock. Drinking itself is more harmful to the body, and many patients with stomach problems should not drink alcohol, so please be sure to pay attention to moderate drinking to avoid affecting their health.