To determine whether the toe pain is gout, you can comprehensively judge from the medical history, symptoms, signs, auxiliary examination and other aspects. 1. Medical history: Toe pain in gout usually occurs without obvious history of toe trauma. Toe pain usually has a sudden onset without obvious triggers, or after overeating and drinking. There is usually a history of multiple episodes of similar disease or a history of hyperuricemia. 2. Symptoms: Gout-induced toe pain, most of the sudden onset in the middle of the night or early in the morning, mainly in the toe joints, unilateral to the 1st metatarsophalangeal joints is the most common. The attack is self-limiting, mostly relieved within 2 weeks. 3. Signs: Gout-induced toe pain is usually accompanied by redness and swelling of the painful joints, increased skin temperature, and limited toe movement. Pressure pain in the painful area is obvious. 4. Auxiliary examination: When gout triggers toe pain, the patient’s blood uric acid is generally high, and joint ultrasonography can see double-track sign or uneven hypoechoic and hypoechoic mixed mass shadow. Joint X-ray examination may find joint soft tissue swelling and irregular joint surface. When toe pain occurs, it is recommended to go to the regular hospital in time, to clarify the cause of the disease, and follow the doctor’s instructions to standardize the diagnosis and treatment.