The diagnostic criteria of intrahepatic cholestasis in pregnancy include typical clinical manifestations, abnormalities in serum bile acids, liver function and other auxiliary tests.
1. Clinical manifestations: patients often have itchy skin in late pregnancy, and some of them may be accompanied by jaundice, etc., and the itchy symptoms will disappear rapidly after delivery.
2. Auxiliary examination: including serum bile acid measurement, liver function measurement, virology examination, liver ultrasound and so on.
(1) Measurement of serum bile acid: it is the main experimental evidence for the diagnosis of intrahepatic cholestasis in pregnancy. Generally fasting serum total bile acid ≥10μmol/L with skin itching can be diagnosed.
(2) Liver function measurements: most patients may have elevated mentholtransferase and alanine transferase, which are often 2 to 10 times the normal level.
(3) Virology examination: diagnosis of intrahepatic cholestasis needs to exclude viral hepatitis and other viral infectious diseases.
(4) Liver ultrasound: It can help to understand the condition of the liver and exclude underlying lesions of the liver and gallbladder, etc.
If there is any discomfort, it is recommended to consult a doctor in time for diagnosis and treatment.