Severe tricuspid regurgitation is treated surgically and medically. For patients with severe tricuspid regurgitation, surgical treatment is preferred, and tricuspid valvuloplasty or repair is given depending on the condition. If these treatments are not effective, tricuspid valve replacement is possible. For some patients who cannot tolerate surgery, diuretic, cardiotonic and vasodilator drugs can be given according to their condition. Commonly used drugs include hydrochlorothiazide, spironolactone, digoxin, and sakubatril valsartan sodium, among which vasodilators help reduce tricuspid regurgitation. The etiology of severe tricuspid regurgitation is mainly tricuspid valve closure insufficiency. The most common primary disease is rheumatic heart valve disease, also seen in congenital heart disease and pulmonary heart disease. Clinical manifestations of body circulation stasis, such as abdominal distention, edema, and hepatomegaly, can also be complicated by atrial fibrillation and pulmonary embolism.