Whether localized thickening of the gallbladder wall by 7 mm is important or not depends on the cause of the disease and cannot be generalized. Cholecystitis, gallbladder adenomyosis and other benign lesions caused by localized thickening of the gallbladder wall 7 mm does not matter, gallbladder cancer and other malignant diseases caused by localized thickening of the gallbladder wall 7 mm is more serious. Acute cholecystitis gallbladder wall will occur congestion and edema, causing gallbladder wall thickening, usually through the levofloxacin, cefixime and other anti-infective treatment after the condition will improve. Chronic cholecystitis will have inflammatory hyperplasia resulting in thickening of the gallbladder wall, generally does not matter, timely cholecystectomy treatment. Adenomyosis of gallbladder refers to the mucosal hyperplasia of the gallbladder which is caught into the muscle layer, causing thickening of the muscle layer, thus leading to thickening of the wall of the gallbladder. Generally, it is a benign lesion, and the condition does not matter, but there is a risk of malignant transformation, which needs to be treated by cholecystectomy. Gallbladder cancer will lead to localized thickening of gallbladder wall, gallbladder cancer will threaten patients’ life, which is more serious, and once found, it needs to be actively treated with comprehensive treatment such as surgery, radiotherapy, chemotherapy and so on. Localized thickening of gallbladder wall of 7mm should go to the hospital in time, improve the examination, and give targeted treatment after clarifying the cause of disease.