High glutamate dehydrogenase may be caused by physiological factors such as alcohol consumption, which is generally not serious; it may also be caused by pathological factors such as chronic hepatitis and cirrhosis, and whether it is serious or not needs to depend on the patient’s own condition, and it is not possible to make a generalization. Glutamate dehydrogenase is a mitochondrial enzyme, which is mainly found in the liver, heart muscle and kidney, and a small amount of glutamate dehydrogenase can also be found in the brain, skeletal muscle and white blood cells. The normal human glutamate dehydrogenase is 0~1.5U/L. If you have eaten oily, high protein food or drink a lot of alcohol before the test, it may affect the test result, and there is a physiological increase, which is usually not serious. However, some diseases can also lead to elevated glutamate dehydrogenase, such as acute viral hepatitis, chronic hepatitis, cirrhosis, etc. However, whether the patient is serious or not depends on the patient’s specific situation, only through a high indicator does not indicate the problem, it is recommended that the patient consults the doctor for the next step in the examination, to clarify the specific causes, and then actively carry out treatment.