Currently there is a lack of research findings on the contraindications of combining silymarin with other drugs, and it is not possible to give a clear answer on which drugs should not be taken together, and the specific use of the drug should be in accordance with the doctor’s instructions. As a hepatoprotective drug, the contraindications and drug interactions of silymarin have not yet been clarified, so there is no clear requirement on the contraindications of drug combination for the time being. The reaction of this drug in combination with other drugs may be affected by the type and dose of the drug used, and the physical condition of the individual, and there may be individual differences in the specific situation. It should also be noted that adverse reactions such as chest tightness and nausea may occur during the use of silymarin. Therefore, if there is a need for the combination of silymarin and other drugs, the drug should be used under the guidance of a doctor, and the efficacy and reaction of the drug should be closely observed, and any discomfort should be promptly treated by a doctor. Do not blindly use the drug or increase or decrease the dosage on your own to avoid adverse effects.