Metronidazole can treat toothache. Toothache is mostly due to mixed bacterial infection causing pulpitis or periodontal inflammation. Metronidazole is an anti-inflammatory drug that is effective against anaerobic bacterial infections in the mouth. When the inflammation in the mouth is eliminated, it will relieve the symptoms of toothache to a great extent. But simply taking metronidazole tablets to reduce inflammation is still not enough, but also need to be combined with cephalosporin, erythromycin or amoxicillin to reduce inflammation. For severe tooth pain due to pulpitis and acute periapical inflammation, pain medication such as ibuprofen can be taken to relieve the pain, while the corresponding dental disorder should be treated promptly by a doctor. Pulpitis and periapical inflammation require root canal treatment, periodontitis requires periodontal systemic treatment, and wisdom tooth extraction is required for periapical inflammation. If the toothache is caused by trauma or tooth fracture, the tooth should be preserved as much as possible, or extracted if it is impossible to preserve it.