Irregular and painful breast nodules are commonly caused by breast glandular hyperplasia, inflammatory nodules and so on. 1. Mammary gland hyperplasia: patients will experience localized pressure and swelling, glandular hyperplasia itself will lead to localized pain, patients should pay attention to emotional control, maintain hormonal balance in order to alleviate the phenomenon of nodal pain. 2. Inflammatory nodules: if the patient has generalized fever and other symptoms on the basis of pain, the cause can be determined according to the nature of the nodule, for breast nodules with pain symptoms, should distinguish whether there are inflammatory diseases. Breastfeeding women are prone to inflammatory diseases of the breast, and most of the nodules are caused by milk stagnation. The infection can be controlled by drainage or antibiotics. Meanwhile, irregular and painful breast nodules do not exclude the possibility of malignant tumors and breast tuberculosis nodules. Patients with irregular and painful breast nodules should be actively treated and choose regular hospitals for regular review.