Intractable angina refers to patients with angina pectoris who are not treated with classical anti-anginal drugs (nitrates, calcium antagonists, β-blockers, angiotensin-converting enzyme inhibitors) and who are not treated with all current treatments for angina pectoris, and who are not suitable for intracoronary intervention or coronary artery bypass grafting. The increasing number of patients with intractable angina pectoris has become a thorny problem in clinical treatment. Scholars at home and abroad have conducted many new studies and explorations for this purpose in recent years, and have made some progress. It can be briefly summarized as follows. Anti-platelet therapy: Studies have shown that the combination of clopidogrel and aspirin can reduce cardiovascular events by 20% in patients with unstable angina. 2, anticoagulation therapy: low molecular heparin can relieve angina symptoms and improve exercise tolerance. 3, improve myocardial metabolism: in myocardial ischemia and hypoxia, inhibit free fatty acid metabolism and increase glucose metabolism, which can increase the energy supply of the heart. A large number of foreign research data show that trimetazidine can reduce the number of angina attacks and improve exercise tolerance. 4, non-pharmacological treatment: for all drug treatment is ineffective, and not suitable for intracoronary intervention or coronary artery bypass grafting patients with intractable angina pectoris, foreign countries in recent years and non-pharmacological treatment research, and has made some progress, such as spinal cord electrical stimulation (dilate heart vessels, increase the threshold of angina pectoris), enhanced extracorporeal counterpulsation (can promote coronary collateral circulation), and laser revascularization (using a laser to punch holes in the myocardium, so that the oxygen content of the left ventricle can be increased. This allows oxygenated blood from the left ventricle to flow through the small laser-made orifice to the myocardium, where it is perfused). Heart transplantation is the last option for patients for whom all methods have failed. However, there are few donors for heart transplantation and the long-term survival rate remains to be seen. 5.Psychotherapy: Recent studies have found that depression is an independent risk factor for the onset and exacerbation of coronary heart disease. Studies have confirmed that the cardiovascular death rate can increase 4.1 times after the combination of depression in coronary heart disease, and most patients die within 6 months after the onset of the disease. However, many cardiologists currently do not pay attention to the psychological status of patients and the diagnosis of depression. Therefore, psychological treatment of depression should also be paid attention to patients with intractable angina pectoris.