Enlarged liver is a kind of clinical sign, to determine whether it is serious or not, we need to clarify the specific causes of the disease, and then determine the severity of the disease according to the relevant causes and the degree of liver enlargement. Enlarged liver may cause fever, fatigue, emaciation, skin jaundice, dark color, ascites, liver palm, spider nevus and other symptoms, and due to the enlarged liver to make the hepatic peritoneum tense, and there will be pain, pressure pain and so on. Some severe hepatomegaly may lead to serious complications such as upper gastrointestinal bleeding, hepatorenal syndrome, hepatic encephalopathy and so on. There are many causes of hepatomegaly, including infectious causes such as viral, bacterial, fungal, mycoplasma, spirochete, and parasitic infections. Liver enlargement due to these causes usually improves effectively with timely treatment to eliminate the associated pathogens. Non-infectious etiologies, including toxic and pharmacological factors can lead to hepatitis; stasis, such as congestive heart failure and other diseases leading to hepatic stasis; cholestasis; metabolic disorders, such as fatty liver, hepatomegaly, etc.; tumors and cysts; and hematological disorders, such as leukemia. Some of these causes are more difficult to treat and therefore may be more serious. It is recommended to consult a doctor in time after liver enlargement occurs, actively identify the cause of the disease and then carry out the corresponding treatment, which can actively and effectively improve the cause of the disease and alleviate the symptoms generally will not lead to very serious consequences.