Chronic urticaria is difficult to cure, there is no magic trick, but through regular treatment to control the symptoms, reduce or eliminate skin lesions, improve the quality of life. Chronic urticaria is mainly characterized by irregular skin eruptions or erythema, and the duration of the disease is more than 6 weeks. Its cause is complex, difficult to specify, often recurring, there is a poor therapeutic effect or treatment is discontinued after the recurrence, so it is difficult to cure. Patients should actively search for and remove the cause of the disease, control and relieve the symptoms through drugs, antihistamines are the first choice of drugs, such as loratadine, cetirizine and so on. When conventional antihistamines are ineffective, glucocorticosteroids such as prednisone, leukotriene inhibitor montelukast, and biologics such as omalizumab can be chosen. When patients develop chronic urticaria, they should seek medical attention, and the use of drugs should be carried out in accordance with medical advice.