The main reasons for sudden generalized numbness include mental factors, Guillain-Barre syndrome, and vegetative nerve dysfunction. 1. Psychological factors: If the patient is accompanied by anxiety and depression, the symptoms of sudden generalized numbness may appear. 2. Guillain-Barre Syndrome: The disease usually develops from distal to proximal, and patients may feel symptoms such as sudden generalized numbness. Combined with cerebrospinal fluid examination, the diagnosis is made. 3. Vegetative nerve dysfunction: this disease is mainly related to the patient’s excessive psychological pressure, irregular life and so on. At the onset of the disease, due to the vegetative nerve dysfunction, the patient will feel numbness all over the body suddenly, accompanied by anxiety-depression and other emotions. There may also be other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.