Soreness in the palm of the hand may be caused by overwork, injury, carpal tunnel syndrome and other reasons. 1. Overexertion: It may be caused by long-term extension or contraction of the hand, which may cause the muscles of the palm to accumulate a large amount of lactic acid, thus giving rise to the symptoms of soreness in the palm, which is a normal physiological phenomenon and can be relieved after rest. 2. Injury: It may be due to the frequent lifting of heavy objects or weight-bearing exercise, resulting in damage to the muscles and ligaments in the palm of the hand, resulting in soreness in the palm of the hand. 3. Carpal tunnel syndrome: It is a syndrome in which the median nerve is compressed in the carpal tunnel, which may be caused by wrist sprain and contusion, chronic injury of the wrist and so on. As the nerve can be compressed, patients may have soreness in the palm of the hand. Soreness in the palm of the hand caused by exertion can be properly rested and temporarily observed. If the palmar pain persists or is caused by other factors, it is recommended to go to the hospital in a timely manner, and follow the doctor’s instructions for treatment, so as not to delay the condition.