In general, a high PGR of 22.05 does not require treatment. The so-called PGR refers to the ratio of pepsinogen 1 to pepsinogen 2 in the blood test, and these two pepsinogens are mainly secreted by the main cells of the gastric fundus, so an abnormal PGR also means that there is a problem with the secretion of the gastric fundus cells. The normal value of PGR is ≥7.5 ng/ml, and the patient’s high PGR of 22.05 is within the normal range, indicating that the fundus cells are also functioning normally, so no treatment is needed. In addition, if the PGR is between 3~7.5ng/ml, it indicates that there may be H. pylori infection in the stomach or gastric mucosal inflammation such as gastric ulcer, etc., and anti-Hp quadruple therapy is needed, which refers to the combination of metronidazole, amoxicillin, omeprazole, and bismuth potassium citrate, which are the four drugs to treat the above diseases. If the PGR is less than 3.0ng/ml, it means that the secretion function of gastric glands is not good, and there is a possibility of glandular atrophy, suggesting that the risk of atrophic gastritis or gastric cancer is higher, and it is necessary to go to the hospital in time to do a gastroscopy and improve the examination of tumor markers. It is worth noting that all of the above drugs should be used under the guidance of a doctor, avoid self-medication. It is recommended that patients with the above conditions go to regular hospitals for timely consultation and standardized treatment under the guidance of specialists to avoid delays.