Uremic patients’ terminal manifestations may be severe respiratory distress, coma, gastrointestinal bleeding or general convulsions. The role of kidney in the human body is very large, the most important role is still detoxification, drainage, the patient into the uremic phase of detoxification, drainage ability will be reduced or even lost. Some patients with uremia have very high blood pressure, with systolic blood pressure reaching 200 mmHg or more, resulting in brain hemorrhage and coma; some patients with uremia have gastrointestinal bleeding, with repeated vomiting of blood, black blood and blood in the stool, resulting in death due to excessive blood loss. Uremic patients are prone to hyperkalemia, which is mainly related to eating too many vegetables and fruits. Hyperkalemia can easily cause malignant arrhythmias, and the patients will show generalized convulsions when they have an attack.