When laboratory tests are performed on patients suffering from sepsis, the white blood cell count is significantly increased, usually up to (20-30)x109/L or more, or decreased, left-shifted, or increased naive type, and toxic granules appear. So, how is the presence of toxic granules diagnosed? The following is the diagnosis of the appearance of toxic granules: The main manifestations of sepsis are: 1. Headache, dizziness, nausea, vomiting, abdominal distension, pale or flushed face, cold sweat. Indifference or irritability, delirium and coma; 2. Accelerated heart events, fine and rapid pulse, shortness of breath or difficulty; 3. Sudden chills, followed by high fever up to 40-41℃, or low temperature, rapid onset, heavy condition and rapid development; 4. Liver and spleen may be enlarged, and jaundice or subcutaneous hemorrhagic bruises may appear in severe cases. Laboratory tests: 1, there may be varying degrees of acidosis, azotemia, hemolysis, protein, blood cells, ketone bodies in the urine, metabolic imbalance and signs of liver and kidney damage; 2, the white blood cell count is significantly higher, usually up to (20-30) x109/L or more, or lower, left shift, increased naive type, the appearance of toxic particles; 3, chills and fever when the blood for bacterial culture. It is easier to find bacteria. If the disease develops and the infection is not controlled, infectious shock and acute development of multi-organ insufficiency or even failure may occur. The clinical manifestations of sepsis still have some differences depending on the causative organisms of the infection.