When laboratory tests are performed on patients suffering from sepsis, the white blood cell count is significantly increased, usually up to (20-30) x109/L or more, or reduced, left-shifted, or increased in the naive type, and toxic granules appear. Toxic particles are produced because patients suffering from sepsis have significantly higher white blood cell counts, usually up to (20-30) x109/L or more, or lowered, left-shifted, or increased naive type, and toxic particles appear. Their treatment is mainly to actively treat primary infectious lesions and reasonably use antibiotics; local skin cleaning and disinfection should be strengthened for long-time intravenous placement and urinary catheterization, etc. Patients who use glucocorticoids, immunosuppressants and anticancer drugs for a long time have low organism resistance to disease, so they should be well protected and isolated while strengthening nutrition and improving physical quality. 1.Septic shock should be resuscitated target treatment for 6 hours after diagnosis, so that heart rate, blood pressure and urine output can reach a satisfactory level. 2.The effect of fluid resuscitation is not related to the nature of the fluid, but mainly related to the amount of fluid infusion. In those whose blood pressure is still unsatisfactory after fluid resuscitation, the use of antihypertensive drugs, norepinephrine or dopamine is preferred. 3.Recommend the use of small doses of hydrocortisone (<300 mg/d). 4.Maintain hematocrit at about 30% and strictly control blood glucose. 5.In acute lung injury/acute respiratory distress syndrome (ALI/ARDS) for mechanical ventilation treatment, use small tidal volumes, allow hypercapnia to exist, and when sedation is required for mechanical ventilation, intermittent use should be used, and neuromuscular blocking agents should be avoided. 6.Use continuous renal replacement therapy when combined with renal failure. 7. pH>7.15 is not recommended for alkaline drugs. 8, Activated protein C therapy is effective, but be alert to the risk of bleeding. 9.Use low molecular weight heparin to prevent deep vein thrombosis. 10.Apply H2 receptor antagonist to prevent stress ulcers.