The difference between cefixime and amoxicillin clavulanate potassium lies in its indications, contraindications, adverse reactions and pharmacologic effects. 1. Indications: Cefixime is suitable for bronchitis, pyelonephritis, cholecystitis, otitis media caused by pneumococcus, Escherichia coli, Aspergillus and other bacteria; Amoxicillin Clavulanate Potassium is mainly used for the treatment of purulent tonsillitis, acute bronchitis or acute exacerbation of chronic bronchitis. 2. Contraindications: Cefixime is prohibited for those who are allergic to cephalosporin; Amoxicillin Clavulanate Potassium is prohibited for those who have severe hepatic impairment, infectious mononucleosis and lymphocytic leukemia. 3. Adverse reactions: the common adverse reactions of cefixime include shock, allergic symptoms, skin lesions and granulocyte deficiency; the common adverse reactions of amoxicillin clavulanate potassium include abdominal distension, nausea, vomiting and other gastrointestinal tract injuries, as well as liver damage. 4. Pharmacological effects: Cefixime is mainly through the prevention of cell wall synthesis, thus leading to bactericidal effect; Amoxicillin Clavulanate Potassium is mainly through the inhibition of cell wall synthesis and inhibition of β-lactamase to achieve bactericidal effect. Cefixime and Amoxicillin Clavulanate Potassium are both commonly used antibiotics in the clinic and should be used under medical supervision.