Bleeding during non-menstrual period may be caused by ovulation bleeding, uterine fibroids, cervicitis, etc. Bleeding caused by unstable hormone level during ovulation usually does not need medication, and disease-induced bleeding during non-menstrual period needs symptomatic medication, and commonly used medications include mifepristone, cefixime, and so on. Part of the disease caused by non-menstrual bleeding, oral medication is not effective, the need for surgical treatment. 1. Uterine fibroids: some patients with uterine fibroids can cause irregular vaginal bleeding during non-menstrual periods, and drugs such as mifepristone can be used to reduce the size of the fibroids and alleviate the symptoms. For patients with large fibroids and obvious bleeding symptoms, surgery is recommended. 2. Cervicitis: this disease is related to pathogen infection, vaginal flora disorders and other factors, vaginal and cervical mucosal congestion and edema, which can cause bleeding during non-menstrual periods. It can be treated with drugs such as azithromycin and cefixime under the guidance of physicians. Some diseases cause bleeding during non-menstrual period, the effect of oral drugs is not good, need surgical treatment, such as cervical polyps, uterine submucosal fibroids, etc. Bleeding during non-menstrual period should go to the hospital in time, under the guidance of the physician to carry out the relevant treatment, and strictly comply with the doctor’s prescription medication.