Acquired herpetic epidermolysis bullosa is an autoimmune disorder characterized by lesions such as blisters, scarring, and milia over friction-prone areas of the skin. Diagnosis can be assisted by history, physical examination, immunohistochemistry, and transmission electron microscopy.
1. Medical history: Acquired herpetic epidermolysis bullosa may have a history of recurrent blistering, ulceration, and itching at friction-prone areas of the skin, and there is no family history of herpetic epidermolysis bullosa.
2. Physical examination: Acquired herpetic epidermolysis bullosa may present with blisters, blisters, scarring, and milia in friction-prone areas of the skin, which may be accompanied by crusting and desquamation.
3. Immunohistochemistry: antibodies against type VII collagen are present in the serum, and direct immunofluorescence shows that IgG and C3 are deposited in the epidermal-dermal junction in a linear fashion.
4. Transmission electron microscopy: Immunoelectron microscopy showed that IgG was deposited in the lower part of the dense plate or in the area below.
Patients with acquired herpetic epidermolysis bullosa should seek prompt medical attention, complete relevant tests and standardize treatment under the guidance of physicians.