A high urine albumin to urine creatinine ratio usually suggests positive proteinuria. It may be caused by physiological reasons such as fever, strenuous exercise, or pathologic reasons such as glomerulonephritis and early diabetic nephropathy. 1. Physiological reasons: more common in strenuous exercise, fever, etc., the patient’s kidneys have no organic lesions, no special treatment, after resting, the urine protein can usually turn negative by itself. 2. Pathologic causes: (1) Glomerulonephritis: glomerulonephritis may cause immune dysfunction, producing in situ immune complexes as well as circulating immune complexes, leading to the destruction of the glomerular basement membrane structure, resulting in the destruction of the glomerular filtration barrier, leading to the appearance of urinary protein. (2) Early diabetic nephropathy: Diabetic nephropathy is one of the most common microvascular complications of diabetes. The early stage of diabetic nephropathy can be manifested as microalbuminuria, etc., and the appearance of high urine albumin and urine creatinine ratio. High urine albumin and urine creatinine ratio may also have other reasons, it is recommended that patients go to regular hospitals in a timely manner, improve the examination to clarify the cause of the disease, and then under the guidance of the doctor to give targeted treatment or therapy.