A high IgG value for neonatal cytomegalovirus represents a previous cytomegalovirus infection in the neonate, most often caused by direct vertical transmission from the mother during pregnancy, and if IgM is negative, no specific treatment is usually required. 1. If the baby is purely IgG-positive after birth, it only means that the baby has been infected in the past. If the liver and kidney functions are normal and the DNA copy number is low, it suggests that the body is recovering gradually, and there is usually no special clinical symptom, so the baby should be followed up regularly and the cytomegalovirus antibody should be rechecked. 2. If the newborn is positive for cytomegalovirus IgM, DNA copy number > 500 pg/mL, and liver damage exists in liver function test, it suggests that the body is in the state of cytomegalovirus infection, and antiviral treatment should be timely. In conclusion, when the value of neonatal cytomegalovirus IgG is high, timely neonatal consultation is recommended, and targeted treatment should be taken if necessary.