Blistering of lips due to fire is generally referred to as mouth ulcers, which are different from herpes in terms of causes, symptoms, and treatment modalities. In terms of etiology, mouth ulcers are more complex and are associated with a variety of factors such as diet, infection, and endocrinology, while herpes is caused by herpes virus infection. In terms of symptoms, mouth ulcers occur in the lips, tongue, cheek mucosa, etc., usually in small quantities, and herpes of the mouth and lips usually appear in the corners of the mouth, the edge of the lips, and localized dense pinhead-sized blisters. In terms of treatment modalities, mouth ulcers can be treated with topical medications such as watermelon cream. Herpes can be treated with oral antiviral medications such as acyclovir and vasiclovir. If there are abnormalities such as blisters on the lips, go to the hospital in time to identify them, and follow the doctor’s instructions when using the above medications.