Whether endometrial thickening of 1.5 centimeters is serious or not needs to be judged on a case-by-case basis, and may be less serious or more serious. 1. Not too serious: If endometrial thickening of 1.5 cm is a benign lesion, it is generally not serious and may be caused by endometritis or endometrial polyps, which can be gradually recovered through regular treatment. 2. More serious: if endometrial thickening of 1.5 cm is endometrial cancer and other diseases, which is relatively more serious, you need to actively seek medical treatment for surgical treatment, resection of the lesion, and at the same time, you also need to cooperate with radiotherapy or targeted drug treatment. Normally, it is necessary to observe more about one’s physical condition, if there is any abnormality, it is better to consult a doctor in time.